Investigating how HIV and amyloid-beta may worsen memory problems in older adults
Routes to Enhanced HIV Neuropathogenesis Through Expression of Subclinical Levels of Endogenous Amyloid-Beta
This study is looking at how HIV and a protein linked to Alzheimer's might work together to affect memory in older adults, using mice to help find better treatments for those who struggle with thinking and memory problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10608763 on NIH RePORTER |
What this research studies
This research explores the interaction between HIV infection and amyloid-beta, a protein associated with Alzheimer's disease, to understand how they may jointly contribute to memory impairments in older adults. The study uses mouse models to simulate the effects of HIV and amyloid-beta on cognitive function, particularly focusing on how these factors may exacerbate neurocognitive impairments. By examining these interactions, the research aims to identify mechanisms that could lead to improved treatments for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who are living with HIV and may be experiencing cognitive decline.
Not a fit: Patients under the age of 65 or those without HIV may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating memory impairments in older adults living with HIV.
How similar studies have performed: Previous research has indicated potential interactions between HIV and neurodegenerative processes, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Volsky, David J — Icahn School of Medicine at Mount Sinai
- Study coordinator: Volsky, David J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.