Investigating how HIV affects the immune system in the brain using specially designed mice
Examining HIV-mediated disruption of CNS immune homeostasis using a triple humanized mouse
This study is looking at how HIV affects the brain and immune system, using special mice that act like humans, to find out more about the brain problems that can happen with HIV and to help discover new treatments for those issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10705753 on NIH RePORTER |
What this research studies
This research focuses on understanding how HIV infection disrupts the immune balance in the central nervous system (CNS). By creating a unique mouse model that mimics human immune and brain cells, researchers aim to explore the interactions between HIV and brain cells, particularly in relation to neurocognitive disorders associated with HIV. The study will help identify how persistent HIV reservoirs in the CNS contribute to chronic inflammation and neurological issues. This innovative approach could provide insights into potential treatments for HIV-related brain disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may be experiencing cognitive difficulties or neurocognitive disorders.
Not a fit: Patients who are not infected with HIV or do not exhibit any neurological symptoms related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from HIV-associated neurocognitive disorders.
How similar studies have performed: While there have been studies on HIV and the CNS, this specific approach using a triple humanized mouse model is relatively novel and has not been extensively tested.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Gorantla, Santhi — University of Nebraska Medical Center
- Study coordinator: Gorantla, Santhi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.