Investigating how HIV affects the human brain using brain tissue cultures
Adult human brain tissue cultures to study neuroHIV
['FUNDING_R21'] · DREXEL UNIVERSITY · NIH-10817140
This study is looking at how HIV affects thinking and memory by using brain tissue from donors, and it aims to help find better treatments for people dealing with cognitive issues related to HIV.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DREXEL UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10817140 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the effects of HIV on cognitive function by using human brain tissue cultures. By collaborating with neurosurgeons, the team will obtain normal human brain tissues and study how HIV interacts with these cells. They will isolate specific immune cells from donors, infect them with HIV, and observe the effects on brain cultures. This approach aims to create a more accurate model of HIV-associated neurocognitive disorder, which could lead to better therapies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are HIV-positive and experiencing cognitive impairments.
Not a fit: Patients who are HIV-negative or do not have cognitive impairments related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in patients living with HIV.
How similar studies have performed: While there has been extensive research on HIV and cognitive disorders, this specific approach using human brain tissue cultures is relatively novel.
Where this research is happening
PHILADELPHIA, UNITED STATES
- DREXEL UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MEUCCI, OLIMPIA — DREXEL UNIVERSITY
- Study coordinator: MEUCCI, OLIMPIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.