Investigating how HIV affects the development of Kaposi's sarcoma using advanced mouse models
(PQ6) Mesenchymal stem cell based and immunocompetent mouse models of HIV/AIDS KSHV-driven sarcomagenesis
This study is looking at Kaposi's sarcoma, a cancer linked to HIV/AIDS, by creating special mouse models to better understand how the disease develops and to find new treatments that could help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11120832 on NIH RePORTER |
What this research studies
This research focuses on understanding Kaposi's sarcoma, a cancer associated with HIV/AIDS, by developing innovative mouse models that mimic the disease. The researchers aim to create in vitro and in vivo systems to study how HIV and the tumor microenvironment contribute to cancer development. By using mesenchymal stem cells and immunocompetent mice, the study seeks to identify new therapeutic approaches and test immune-based therapies for better treatment outcomes. Patients may benefit from insights gained through these models that could lead to improved therapies for AIDS-related cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV/AIDS who are at risk for developing Kaposi's sarcoma or other related cancers.
Not a fit: Patients who do not have HIV/AIDS or who are not at risk for Kaposi's sarcoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new and effective treatments for Kaposi's sarcoma and other AIDS-related malignancies.
How similar studies have performed: Previous research has shown promise in using animal models to study cancer development related to HIV, indicating that this approach may yield valuable insights.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Shembade, Noula Dattu — University of Miami School of Medicine
- Study coordinator: Shembade, Noula Dattu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.