Investigating how HIV affects the brain and the role of opioids
A new brain organoid model for NeuroHIV and the impact of opioids
This study is looking at how HIV affects the brain and how opioids might change those effects, using special lab-grown brain models to help find better treatments for people dealing with HIV-related brain issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10914900 on NIH RePORTER |
What this research studies
This research focuses on understanding the effects of HIV on the central nervous system (CNS) and how opioids may influence these effects. By using advanced brain organoid models, which are 3D structures that mimic human brain tissue, researchers aim to explore the mechanisms behind HIV-associated neurological disorders. The study seeks to identify the interactions between HIV and various cell types in the brain, providing insights that could lead to better treatments for those affected. This innovative approach allows for a more accurate representation of human brain responses compared to traditional animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who are experiencing neurological symptoms or disorders.
Not a fit: Patients who are not living with HIV or do not have neurological symptoms related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for neurological disorders associated with HIV.
How similar studies have performed: Other research using brain organoid models has shown promise in studying neurological diseases, indicating that this approach may yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Muotri, Alysson R. — University of California, San Diego
- Study coordinator: Muotri, Alysson R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.