Investigating how HIV affects aging and the immune system using humanized mice.
Official title: Exploring the Molecular, Neuro-immune and Behavioral changes during HIV-associated progressive aging using a long-term humanized mice model
Funded at University of Nebraska Medical Center · NIH-11170144 · Data updated 2026-11-12
This study is looking at how living with HIV might make people age faster, especially in terms of their immune system and behaviors, and it aims to find out how treatments can help improve health and well-being for those with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $383,750 |
| NIH project number | 1R56AG087827-01 |
| Project ID | NIH-11170144 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 50 and older who are living with HIV.
✕Less likely to help
Patients who are not living with HIV or those who are younger than 50 may not receive benefits from this research.
What this research studies
This research explores the relationship between HIV infection and accelerated aging, particularly focusing on the immune system and behavioral changes in individuals living with HIV. By utilizing a long-term humanized mice model, the study aims to understand how HIV contributes to inflammation and other age-related health issues. The researchers will analyze the effects of antiretroviral therapy on aging processes and brain health, providing insights into potential therapeutic targets for improving the quality of life for those affected by HIV.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that mitigate the effects of aging in people living with HIV.
How similar studies have gone: Previous research has shown that understanding the interplay between HIV and aging can lead to significant advancements in treatment strategies, indicating that this approach has potential for success.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Dash, Prasanta Kumar — University of Nebraska Medical Center
- Study coordinator: Dash, Prasanta Kumar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.