Investigating how HIV-1 reservoirs form and decay over time
Understanding reservoir dynamics through analysis of viral decay processes
This study is looking at how HIV-1 behaves in infected cells and how it decreases when people start treatment, with the goal of finding better ways to manage the virus for those living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11079488 on NIH RePORTER |
What this research studies
This research focuses on understanding the dynamics of HIV-1 reservoirs by analyzing how the virus decays in infected cells. It employs single-cell analysis to track the processes that determine the composition of these reservoirs, particularly after the initiation of antiretroviral therapy (ART). The study aims to clarify the identity and fate of cells that contribute to viral decay, which is crucial for developing effective treatments. By examining the rapid and biphasic decay of the virus, researchers hope to uncover insights that could lead to better management of HIV-1.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1 who are undergoing antiretroviral therapy.
Not a fit: Patients who are not infected with HIV-1 or those who are not receiving antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing HIV-1 and potentially finding a cure.
How similar studies have performed: Previous studies have shown success in understanding HIV dynamics, but this specific approach to analyzing viral decay processes is novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Siliciano, Robert F — Johns Hopkins University
- Study coordinator: Siliciano, Robert F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.