Investigating how HIV-1 persists in immune cells
Understanding HIV-1 persistence in cytotoxic CD4+ T lymphocytes at the single cell level
This study is looking at how HIV-1 stays in the body even when people are on effective treatment, and it’s for individuals living with HIV-1 to help find new ways to improve their care by understanding the immune cells involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11074636 on NIH RePORTER |
What this research studies
This research focuses on understanding how HIV-1 survives and persists in the body despite effective antiretroviral therapy (ART). By examining CD4+ T cells from individuals living with HIV-1, the study aims to identify the immune cell subsets and markers associated with HIV-1 infection. Using advanced techniques like single-cell ECCITEseq, researchers will analyze the characteristics of these cells at a detailed level, which may reveal new therapeutic targets for treatment. The goal is to better understand the mechanisms of HIV-1 persistence to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1 who are currently on antiretroviral therapy and have achieved viral suppression.
Not a fit: Patients who are not living with HIV-1 or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for eliminating HIV-1 from the body and improving treatment for patients living with the virus.
How similar studies have performed: Other research has shown promise in understanding HIV-1 persistence using similar advanced single-cell analysis techniques, indicating a potential for success in this approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Ho, Ya-Chi — Yale University
- Study coordinator: Ho, Ya-Chi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.