Investigating how HIV-1 persists in immune cells
Official title: Understanding HIV-1 persistence in cytotoxic CD4+ T lymphocytes at the single cell level
Funded at Yale University · NIH-11074636 · Data updated 2026-11-12
This study is looking at how HIV-1 stays in the body even when people are on effective treatment, and it’s for individuals living with HIV-1 to help find new ways to improve their care by understanding the immune cells involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 11, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $840,074 |
| NIH project number | 5R01AI174863-03 |
| Project ID | NIH-11074636 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV-1 who are currently on antiretroviral therapy and have achieved viral suppression.
✕Less likely to help
Patients who are not living with HIV-1 or those who are not on antiretroviral therapy may not benefit from this research.
What this research studies
This research focuses on understanding how HIV-1 survives and persists in the body despite effective antiretroviral therapy (ART). By examining CD4+ T cells from individuals living with HIV-1, the study aims to identify the immune cell subsets and markers associated with HIV-1 infection. Using advanced techniques like single-cell ECCITEseq, researchers will analyze the characteristics of these cells at a detailed level, which may reveal new therapeutic targets for treatment. The goal is to better understand the mechanisms of HIV-1 persistence to improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for eliminating HIV-1 from the body and improving treatment for patients living with the virus.
How similar studies have gone: Other research has shown promise in understanding HIV-1 persistence using similar advanced single-cell analysis techniques, indicating a potential for success in this approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Ho, Ya-Chi — Yale University
- Study coordinator: Ho, Ya-Chi
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Adapting a mobile health tool to boost HIV outcomes for older adults with HIV in Ukraine
A mobile health platform called PositiveLinks would be adapted for older adults with HIV in Ukraine to help them stay engaged in care and improve treatment success.
-
Behavioral and neural links between spoken language sounds and written words in young children
This grant studies how young children learn from listening and reading to improve literacy, by looking at how sound patterns transfer to written language.
-
Understanding how autoimmunity causes myasthenia gravis
This project looks at why the immune system attacks the nerve-muscle connection in myasthenia gravis and how different patient groups are affected.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.