Investigating how HIV-1 persists in brain immune cells
HIV-1DetectionandEliminationFrom CNS Mononuclear Phagocytes
['FUNDING_R01'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-10915729
This study is looking at how HIV-1 hides in certain immune cells in the brain and why these cells matter for people living with HIV, with the goal of finding new ways to help get rid of the virus even when treatment is ongoing.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-10915729 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how HIV-1 hides in mononuclear phagocytes, which are immune cells in the brain, and why these cells are important in the disease process for people living with HIV. The study aims to explore the dynamics of HIV-1 infection in the central nervous system, particularly how the virus interacts with these immune cells and contributes to ongoing viral persistence despite antiretroviral therapy. By examining the characteristics of these cells and their role in the brain, the research seeks to identify potential new strategies for eliminating the virus from the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently receiving antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively eliminate HIV-1 from the central nervous system, improving health outcomes for people living with HIV.
How similar studies have performed: Previous research has shown promise in understanding HIV reservoirs in other tissues, but this specific focus on the central nervous system and mononuclear phagocytes is relatively novel.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GORANTLA, SANTHI — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: GORANTLA, SANTHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus