Investigating how HIV-1 matures and how inhibitors affect this process
Official title: Molecular investigations of HIV-1 maturation pathways and inhibitor actions in situ
Funded at Yale University · NIH-11190223 · Data updated 2026-11-12
This study is looking at how the HIV-1 virus changes and grows inside infected cells, using special imaging techniques, to find new ways to treat the virus and help people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 24, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $859,992 |
| NIH project number | 1R01AI192025-01 |
| Project ID | NIH-11190223 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV-1 who are undergoing treatment or are treatment-naive.
✕Less likely to help
Patients with other types of viral infections or those who are not infected with HIV-1 may not benefit from this research.
What this research studies
This research focuses on understanding the maturation process of HIV-1, which is essential for the virus to effectively infect host cells. Using advanced techniques like in situ cryo-electron microscopy, the study aims to visualize the structural changes that occur during HIV-1 maturation within the natural environment of infected cells. By examining both virus-like particles and actual viruses from patients, the researchers hope to uncover critical details about the viral life cycle that could lead to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective therapies for HIV-1 infection.
How similar studies have gone: Previous research has shown promise in understanding viral maturation processes, but this approach using in situ cryo-EM is relatively novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Xiong, Yong — Yale University
- Study coordinator: Xiong, Yong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.