Investigating how HIV-1 interacts with immune cells using new compounds
Official title: Probing functional HIV-1 envelope glycoprotein conformations with novel potent CD4-mimetic compounds
Funded at Dana-Farber Cancer Inst · NIH-10885202 · Data updated 2026-11-12
This study is looking at how HIV-1 changes when it connects with immune cells, and it's testing new compounds that could help block the virus from entering cells and make antibodies work better, which could lead to new treatments for people living with HIV/AIDS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 10, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $825,965 |
| NIH project number | 5R01AI176904-02 |
| Project ID | NIH-10885202 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV/AIDS who may benefit from innovative treatment approaches.
✕Less likely to help
Patients who are not infected with HIV or those who have advanced stages of the disease with limited treatment options may not benefit from this research.
What this research studies
This research focuses on understanding the structural changes in the HIV-1 envelope glycoprotein when it binds to immune cell receptors. By using novel compounds that mimic the CD4 receptor, the study aims to block HIV-1 from entering cells and to enhance the effectiveness of antibodies against the virus. The approach involves testing these compounds in animal models to observe their impact on HIV-1 infection and immune response. Patients may benefit from insights gained that could lead to new treatments for HIV/AIDS.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the immune response against HIV-1 and reduce viral reservoirs in patients.
How similar studies have gone: Previous research has shown promise in using similar CD4-mimetic compounds to enhance immune responses against HIV, indicating potential for success in this approach.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Sodroski, Joseph G — Dana-Farber Cancer Inst
- Study coordinator: Sodroski, Joseph G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.