Investigating how histones affect cell division and development
Development and Application of a Novel Method to Study Histone Inheritance in Asymmetrically Dividing Cells
This study is looking at how certain proteins called histones affect how stem cells divide and decide what type of cell they will become, using fruit flies as a model, and the goal is to learn more about how this process might relate to health issues like cancer and aging.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10909202 on NIH RePORTER |
What this research studies
This research focuses on understanding how histones, which are proteins that help package DNA, influence the process of asymmetric cell division (ACD) in stem cells. By studying Drosophila male germ cells, the researchers aim to uncover the mechanisms behind histone inheritance and its impact on cell fate determination. The project employs advanced techniques to track histones and their modifications at specific locations within single cells, which could lead to new insights into tissue health and disease. The findings may help clarify the role of chromatin in various conditions, including cancer and age-related degeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to aging, cancer, or other diseases that may involve stem cell dysfunction.
Not a fit: Patients with stable conditions that do not involve stem cell dynamics or chromatin-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for maintaining tissue health and preventing diseases related to cell division errors.
How similar studies have performed: Previous research has shown promising results in understanding chromatin's role in cell division, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Palladino, Jason Thomas — Johns Hopkins University
- Study coordinator: Palladino, Jason Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.