Investigating how histone modifications affect gene regulation
Histone Arginine Demethylation through Cleavage
This study is looking at how certain proteins help control gene activity in our cells, which is important for things like growth and fighting diseases, and it hopes to find new ways to treat conditions like cancer and aging that could help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-10693175 on NIH RePORTER |
What this research studies
This research explores the role of RNA Polymerase II pausing in gene regulation, which is crucial for various cellular functions and responses. It aims to understand how specific proteins, like JMJD5, interact with RNA Polymerase II to modify histones, potentially influencing gene expression. By examining the mechanisms behind histone arginine demethylation, the study seeks to uncover new insights into developmental processes, immune responses, and the progression of diseases such as cancer and aging. Patients may benefit from a better understanding of these processes, which could lead to novel therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cancers or age-related conditions that may be influenced by gene regulation.
Not a fit: Patients with conditions unrelated to gene regulation or those not affected by cancer or aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers and age-related diseases by targeting the mechanisms of gene regulation.
How similar studies have performed: While the specific approach of this research is innovative, similar studies have shown promise in understanding gene regulation and its implications for disease.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Zhang, Gongyi — National Jewish Health
- Study coordinator: Zhang, Gongyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.