Investigating how histone modifications affect gene expression and development
Role of histone PTMs in epigenetic control of metazoan transcription and RNA processing
This study is exploring how tiny changes in proteins called histones can affect how genes work and help fruit flies grow, so researchers can better understand gene regulation in living organisms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11089179 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of histone post-translational modifications (PTMs) in regulating gene expression and development in multicellular organisms. Using innovative models in the fruit fly Drosophila melanogaster, the researchers manipulate specific amino acid residues in histones to observe their effects on cellular pathways and organismal development. By employing advanced genome-wide techniques alongside molecular genetics and biochemistry, they aim to uncover how these modifications influence genetic and epigenetic information transmission.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or cancers that may be influenced by epigenetic changes.
Not a fit: Patients with conditions unrelated to genetic or epigenetic mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of gene regulation, potentially informing treatments for various diseases, including cancers.
How similar studies have performed: Other research has shown success in understanding gene regulation through similar epigenetic approaches, making this a promising area of investigation.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Matera, a. Gregory — Univ of North Carolina Chapel Hill
- Study coordinator: Matera, a. Gregory
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.