Investigating how histone modifications affect gene expression
Role of novel histone modifications and variants in transcriptional regulation
['FUNDING_OTHER'] · EMORY UNIVERSITY · NIH-10891533
This study is looking at how certain changes to proteins that help control our genes might affect how our cells work, especially in relation to diseases like cancer, and it's for anyone interested in understanding more about how our genes are regulated.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10891533 on ClinicalTrials.gov |
What this research studies
This research explores the role of specific modifications to histone proteins, which are crucial for regulating gene expression. By examining how these modifications, particularly a less understood one called H3 threonine 45 phosphorylation, interact with cellular signals, the study aims to uncover mechanisms that influence gene activity. The approach combines various methods, including genetic, molecular, and computational techniques, to provide a comprehensive understanding of how these histone changes can impact cellular functions and contribute to diseases like cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to dysregulated gene expression, such as certain types of cancer.
Not a fit: Patients with conditions unrelated to gene regulation or histone modifications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatments for various diseases, including cancers.
How similar studies have performed: Other research has shown promising results in understanding histone modifications and their impact on gene expression, indicating that this approach has potential for significant findings.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPANGLE, JENNIFER MARIE — EMORY UNIVERSITY
- Study coordinator: SPANGLE, JENNIFER MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers