Investigating how histone modifications affect gene expression
Official title: Role of novel histone modifications and variants in transcriptional regulation
Funded at Emory University · NIH-10891533 · Data updated 2026-11-12
This study is looking at how certain changes to proteins that help control our genes might affect how our cells work, especially in relation to diseases like cancer, and it's for anyone interested in understanding more about how our genes are regulated.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $385,206 |
| NIH project number | 5R35GM150587-02 |
| Project ID | NIH-10891533 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to dysregulated gene expression, such as certain types of cancer.
✕Less likely to help
Patients with conditions unrelated to gene regulation or histone modifications may not benefit from this research.
What this research studies
This research explores the role of specific modifications to histone proteins, which are crucial for regulating gene expression. By examining how these modifications, particularly a less understood one called H3 threonine 45 phosphorylation, interact with cellular signals, the study aims to uncover mechanisms that influence gene activity. The approach combines various methods, including genetic, molecular, and computational techniques, to provide a comprehensive understanding of how these histone changes can impact cellular functions and contribute to diseases like cancer.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatments for various diseases, including cancers.
How similar studies have gone: Other research has shown promising results in understanding histone modifications and their impact on gene expression, indicating that this approach has potential for significant findings.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Spangle, Jennifer Marie — Emory University
- Study coordinator: Spangle, Jennifer Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.