Investigating how histone modifications affect cellular functions
Official title: Biochemical and genomic tools to study histone ADP ribosylation signaling
Funded at Epicypher, INC. · NIH-11030277 · Data updated 2026-11-12
This study is exploring a special chemical change in our cells that affects how they work and is connected to diseases like cancer, and it's creating new tools to help scientists learn more about this change so they can find better treatments for these conditions.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Epicypher, INC. NIH-funded |
| Lab location | 1 site (Research Triangle Park, UNITED STATES) |
| Project start | March 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,274,280 |
| NIH project number | 5R44GM153000-02 |
| Project ID | NIH-11030277 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals with cancers or other diseases linked to histone ADP-ribosylation.
✕Less likely to help
Patients with conditions unrelated to histone modifications or those not currently undergoing treatment for cancer may not receive benefits from this research.
What this research studies
This research focuses on understanding histone ADP-ribosylation, a chemical modification that plays a crucial role in regulating cellular functions and is linked to various diseases, including cancer. The project aims to develop innovative molecular tools that will allow scientists to study this modification in detail, both in living organisms and in laboratory settings. By creating fully-defined designer nucleosomes, the research will provide new insights into how these modifications work and identify potential therapeutic targets for treatment. This could lead to advancements in cancer therapies and other disease treatments.
Why it matters
Potential benefit: If successful, this research could lead to the development of new cancer therapies and improved treatment options for diseases associated with histone modifications.
How similar studies have gone: Other research has shown success in targeting histone modifications for therapeutic purposes, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Epicypher, INC.
Research Triangle Park, United States Active
Researchers
- Principal investigator: Hunt, Sabrina Robin — Epicypher, INC.
- Study coordinator: Hunt, Sabrina Robin
Related research
Other NIH-funded projects on the same topics.
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-
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-
New tools to study how asymmetric histone tweaks control gene activity
A new NIH grant aims to create designer nucleosomes with asymmetric modifications to better understand how gene regulation is influenced by the histone code, which could lead to better biomarkers and therapies for cancer.
-
Epigenomic profiling of cell-free nucleosomes in plasma cancer research
A new test platform analyzes the tiny pieces of DNA wrapped around proteins in blood to help identify cancer signals.
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Scalable single-molecule chromatin accessibility profiling in immune cells
A new approach aims to map which parts of the genome are accessible and which proteins bind them in immune cells, using advanced sequencing on a scale that could reveal detailed cell-by-cell information.
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A New Way to Map DNA Structures Linked to Alzheimer's and Aging
This project is creating a new and more accurate way to map special DNA structures called R-loops, which are connected to aging and brain diseases like Alzheimer's.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.