Investigating how histone modifications affect cellular functions
Biochemical and genomic tools to study histone ADP ribosylation signaling
['FUNDING_SBIR_2'] · EPICYPHER, INC. · NIH-11030277
This study is exploring a special chemical change in our cells that affects how they work and is connected to diseases like cancer, and it's creating new tools to help scientists learn more about this change so they can find better treatments for these conditions.
Quick facts
| Phase | ['FUNDING_SBIR_2'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EPICYPHER, INC. (nih funded) |
| Locations | 1 site (Research Triangle Park, UNITED STATES) |
| Trial ID | NIH-11030277 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding histone ADP-ribosylation, a chemical modification that plays a crucial role in regulating cellular functions and is linked to various diseases, including cancer. The project aims to develop innovative molecular tools that will allow scientists to study this modification in detail, both in living organisms and in laboratory settings. By creating fully-defined designer nucleosomes, the research will provide new insights into how these modifications work and identify potential therapeutic targets for treatment. This could lead to advancements in cancer therapies and other disease treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals with cancers or other diseases linked to histone ADP-ribosylation.
Not a fit: Patients with conditions unrelated to histone modifications or those not currently undergoing treatment for cancer may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new cancer therapies and improved treatment options for diseases associated with histone modifications.
How similar studies have performed: Other research has shown success in targeting histone modifications for therapeutic purposes, indicating that this approach has potential for significant advancements.
Where this research is happening
Research Triangle Park, UNITED STATES
- EPICYPHER, INC. — Research Triangle Park, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUNT, SABRINA ROBIN — EPICYPHER, INC.
- Study coordinator: HUNT, SABRINA ROBIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.