Investigating how high fat diets link obesity to breast cancer risk
Determine the molecular and metabolic mechanisms by which A-FABP links dysregulated lipid metabolism-induced obesity/breast cancer risk
This study is looking at how eating a lot of fatty foods and being overweight might raise the chances of getting breast cancer, focusing on a protein that helps process fats, and it hopes to find new ways to prevent or treat breast cancer linked to obesity.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10898049 on NIH RePORTER |
What this research studies
This research aims to uncover the molecular and metabolic mechanisms that connect high fat diets and obesity to an increased risk of breast cancer. By studying the role of a protein called A-FABP, which is involved in lipid metabolism, the researchers will explore how obesity influences breast cancer development. The study will involve analyzing how different types of high fat diets affect A-FABP expression and the behavior of breast cancer cells. Patients may benefit from insights that could lead to new prevention strategies or treatments targeting obesity-related breast cancer risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese or overweight and may be at risk for breast cancer.
Not a fit: Patients who are not overweight or do not have a family history of breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing breast cancer in individuals with obesity.
How similar studies have performed: Previous research has shown promising results in understanding the links between obesity and cancer, but this specific approach focusing on A-FABP is relatively novel.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Li, Bing — University of Iowa
- Study coordinator: Li, Bing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.