Investigating how high blood pressure affects bone health and osteoporosis in aging Veterans
Official title: BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to Bone (FRACTURE CURB): Role of Hypertension in Favoring Osteoporosis
Funded at Veterans Health Administration · NIH-10950334 · Data updated 2026-11-12
This study is looking at how high blood pressure might affect bone health in older Veterans, and it aims to find new ways to help strengthen bones and prevent fractures using a hormone called parathyroid hormone (PTH).
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | October 1, 2022 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX005866-03 |
| Project ID | NIH-10950334 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are aging Veterans who are at risk for osteoporosis or have hypertension.
✕Less likely to help
Patients who are not Veterans or those who do not have hypertension or osteoporosis may not benefit from this research.
What this research studies
This research focuses on understanding the relationship between hypertension and osteoporosis, particularly in aging Veterans. By utilizing pre-clinical models, the study aims to explore innovative ways to enhance bone formation through the action of parathyroid hormone (PTH). The collaborative effort involves a diverse team of VA investigators who will assess the effects of various health conditions on bone health and develop new strategies for early detection and treatment of osteoporosis. The goal is to improve bone health and reduce the risk of fractures among Veterans.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for osteoporosis, reducing the risk of fractures and enhancing the quality of life for aging Veterans.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between hypertension and bone health, indicating that this approach has potential for success.
Where this research is happening
-
Veterans Health Administration
Nashville, United States Active
Researchers
- Principal investigator: Nyman, Jeffry Stephen — Veterans Health Administration
- Study coordinator: Nyman, Jeffry Stephen
Related research
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How high blood pressure may weaken bones and affect healing
Researchers are working to help aging Veterans with high blood pressure keep bones stronger and heal fractures faster by boosting how parathyroid hormone builds bone.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.