Investigating how hexavalent chromium affects cancer development
MGMT DOWN-REGULATION IN THE CARCINOGENICITY OF HEXAVALENT CHROMIUM
['FUNDING_R01'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-10829055
This study is looking into how exposure to hexavalent chromium, a harmful substance that can cause cancer, affects our cells and DNA, with the goal of finding ways to prevent or treat cancers linked to it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-10829055 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the harmful effects of hexavalent chromium (Cr(VI)), a known carcinogen, on human health. It explores how exposure to Cr(VI) can lead to cancer by examining its impact on genetic and epigenetic changes in cells. The study aims to uncover the mechanisms behind Cr(VI)-induced carcinogenicity, particularly how it alters DNA repair processes and promotes cancer stem cell properties. By analyzing these changes, the research seeks to provide insights into potential therapeutic targets for preventing or treating cancers associated with Cr(VI) exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to hexavalent chromium, particularly those with a history of occupational exposure or living near contaminated sites.
Not a fit: Patients who have not been exposed to hexavalent chromium or do not have related cancer types may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cancers caused by hexavalent chromium exposure.
How similar studies have performed: Previous studies have shown that understanding the genetic and epigenetic mechanisms of carcinogens can lead to significant advancements in cancer treatment, suggesting that this approach has potential for success.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, ZHISHAN — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: WANG, ZHISHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer, Cancer Causing Agents