Investigating how hepatitis B virus integrations in a specific gene contribute to liver cancer.
Hepatitis B virus integrations in KMT2B drive hepatocellular carcinoma
This study is looking at how the hepatitis B virus affects a specific gene linked to liver cancer, and it's for people with liver cancer caused by hepatitis B, as the researchers hope to find new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10893646 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of hepatitis B virus (HBV) integrations in the KMT2B gene and how they contribute to the development of hepatocellular carcinoma (HCC), a type of liver cancer. The researchers have identified specific cell lines derived from patients with HCC that carry these HBV integrations. By studying these cell lines, they aim to uncover the mechanisms by which these genetic changes promote cancer cell growth and proliferation. The ultimate goal is to identify potential therapeutic targets that could lead to better treatment options for patients with HBV-related liver cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hepatocellular carcinoma associated with chronic hepatitis B virus infection.
Not a fit: Patients with liver cancer not associated with hepatitis B virus or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients suffering from liver cancer caused by hepatitis B virus.
How similar studies have performed: Previous research has shown that understanding genetic integrations in cancer can lead to significant advancements in treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Cao, Jian — Rutgers Biomedical and Health Sciences
- Study coordinator: Cao, Jian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.