Investigating how hepatitis B virus behaves in patients with and without HIV
HBV cccDNA transcriptional silencing with and without HIV
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11142428
This study is looking at how the hepatitis B virus works with the immune system in people who also have HIV, to find out how we can better treat and possibly cure those who are dealing with both infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11142428 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the hepatitis B virus (HBV) interacts with the immune system, particularly in individuals who are also infected with HIV. The study aims to explore the mechanisms behind the suppression of HBV DNA in the liver during antiviral treatment, which is crucial for developing a potential cure. By comparing liver samples from patients with HBV alone and those co-infected with HIV, researchers will use advanced techniques to analyze viral behavior at the cellular level. This could lead to new insights into effective treatments for those affected by both viruses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic hepatitis B, particularly those who are also living with HIV.
Not a fit: Patients who do not have chronic hepatitis B or HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and potentially a functional cure for patients with chronic hepatitis B, especially those co-infected with HIV.
How similar studies have performed: Previous research has shown promising results in understanding viral interactions in co-infections, making this approach both relevant and potentially impactful.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BALAGOPAL, ASHWIN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: BALAGOPAL, ASHWIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus