Investigating how hepatitis B virus adapts and resists treatment
Launching HBV with RNA to assess antiviral resistance and explore fundamental aspects of virus-host biology
['FUNDING_R01'] · ROCKEFELLER UNIVERSITY · NIH-11131394
This study is looking at chronic hepatitis B to find new ways to understand how the virus works and why some treatments don’t always work, with the hope that what we learn can help create better options for managing the infection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROCKEFELLER UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11131394 on ClinicalTrials.gov |
What this research studies
This research focuses on chronic hepatitis B virus (HBV) infection, which currently lacks an effective cure. It aims to develop innovative methods to study the biology of HBV and understand how genetic variations in the virus contribute to antiviral resistance. By using a novel HBV RNA launch method and deep mutational scanning, the research will explore how mutations affect disease progression and treatment efficacy. Patients may benefit from insights gained that could lead to new therapeutic strategies for managing HBV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic hepatitis B infection, particularly those experiencing treatment resistance.
Not a fit: Patients without chronic hepatitis B infection or those who have already achieved a cure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively combat chronic hepatitis B virus infection.
How similar studies have performed: Previous research has shown promise in understanding viral resistance mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
NEW YORK, UNITED STATES
- ROCKEFELLER UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RICE, CHARLES M — ROCKEFELLER UNIVERSITY
- Study coordinator: RICE, CHARLES M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers