Investigating how hemolysis affects blood clotting in patients with mechanical heart support devices
Molecular Studies of Hemolytic Thrombosis
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11073842
This study is looking at how the breakdown of red blood cells affects blood clotting in patients using heart support devices, to help find better ways to prevent blood clots and keep you healthier.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11073842 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the complex relationship between hemolysis, which is the breakdown of red blood cells, and thrombosis, or blood clot formation, particularly in patients using mechanical circulatory support devices. The study examines how free hemoglobin released during hemolysis interacts with von Willebrand factor, a key protein in blood clotting, to enhance platelet adhesion and thrombus formation. By analyzing blood samples and the behavior of platelets under various conditions, the research aims to uncover mechanisms that could lead to better management of thrombotic complications in these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who are receiving mechanical circulatory support and are at risk for thrombotic complications.
Not a fit: Patients who do not have mechanical circulatory support devices or those without thrombotic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing thrombosis in patients with mechanical circulatory support devices, enhancing their safety and outcomes.
How similar studies have performed: Previous studies have shown that understanding the interactions between hemolysis and thrombosis can lead to significant advancements in treatment strategies, indicating that this research builds on established findings.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CRUZ, MIGUEL ANGEL — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: CRUZ, MIGUEL ANGEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.