Investigating how hemolysis affects blood clotting in patients with mechanical heart support devices
Molecular Studies of Hemolytic Thrombosis
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10886494
This study is looking at how using heart support devices can cause red blood cells to break down and affect blood clotting, which could help improve treatments for patients who need these devices.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10886494 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the complications that arise from using mechanical circulatory support devices, particularly how hemolysis (the breakdown of red blood cells) influences blood clotting. The study examines the role of free hemoglobin and von Willebrand factor in promoting platelet adhesion and thrombus formation under high shear stress conditions. By analyzing how these factors interact, the research aims to identify potential therapeutic targets to improve patient outcomes. Patients with conditions requiring mechanical support may benefit from insights gained through this investigation.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who are receiving mechanical circulatory support for heart failure or other multi-organ support needs.
Not a fit: Patients who do not require mechanical circulatory support or have no history of thrombotic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients using mechanical circulatory support devices, reducing the risk of thrombosis and bleeding complications.
How similar studies have performed: Previous research has shown that understanding the interactions between hemolysis and blood clotting factors can lead to significant advancements in treating thrombotic complications, indicating a promising avenue for this study.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CRUZ, MIGUEL ANGEL — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: CRUZ, MIGUEL ANGEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.