Investigating how Hedgehog signaling affects muscle repair and fat formation
Ciliary Hedgehog signaling during adult tissue repair and disease
This study is looking at how fat builds up in muscles and affects muscle health, especially for people with Duchenne muscular dystrophy or those experiencing muscle loss as they age, to find new ways to help muscles heal better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11053639 on NIH RePORTER |
What this research studies
This research focuses on understanding how intramuscular fat forms and its impact on muscle health, particularly in conditions like Duchenne muscular dystrophy and age-related muscle loss. The study will explore the role of ciliary Hedgehog signaling in muscle regeneration, using advanced mouse models to identify key signaling pathways and cell types involved. By examining how Hedgehog signaling can balance fat formation and muscle repair, the research aims to uncover new therapeutic strategies for diseases characterized by fatty fibrosis.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults suffering from chronic muscle diseases such as Duchenne muscular dystrophy, sarcopenia, obesity, or diabetes.
Not a fit: Patients with acute muscle injuries or those without chronic muscle conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve muscle health and function in patients with chronic muscle diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of Hedgehog signaling in muscle regeneration, indicating potential for success in this area.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Kopinke, Daniel — University of Florida
- Study coordinator: Kopinke, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.