Investigating how heart stress affects cell signaling and growth
Perinuclear Signaling and Cardiac Hypertrophy
This study is looking at how long-term stress affects the heart and aims to find ways to protect heart cells from damage, which could help develop new treatments for heart problems caused by stress.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-10812515 on NIH RePORTER |
What this research studies
This research focuses on understanding how chronic stress on the heart, particularly through the stimulation of beta-adrenergic receptors, leads to harmful changes in heart cells. It aims to explore the role of specific proteins and calcium signaling in the nucleus of heart cells, which may contribute to heart disease. By blocking certain pathways, the researchers hope to prevent disease progression while preserving the heart's ability to contract effectively. This approach could lead to new treatments for heart conditions caused by chronic stress.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing chronic stress-related heart issues.
Not a fit: Patients with acute heart conditions or those not affected by chronic stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent heart disease without compromising heart function.
How similar studies have performed: Other research has shown promise in targeting similar pathways in heart disease, suggesting that this approach could be effective.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Dodge-Kafka, Kimberly L — University of Connecticut Sch of Med/dnt
- Study coordinator: Dodge-Kafka, Kimberly L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.