Investigating how heart signals affect kidney health in patients with heart disease
Myocyte-to-kidney Signaling in Cardiorenal Nephrosclerosis and Hypertension
This study is looking at how heart problems that land people in the hospital can lead to long-term kidney issues, especially in veterans, and it aims to find ways to help improve kidney health after heart recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11003740 on NIH RePORTER |
What this research studies
This research explores the connection between acute cardiorenal syndrome, which often follows heart-related hospital admissions, and the development of chronic kidney disease. It focuses on understanding the mechanisms that lead to long-term kidney issues after heart problems, particularly in veterans. Using animal models, the study examines how specific factors released during heart recovery can influence kidney function and blood pressure regulation. The ultimate goal is to identify potential interventions that could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans who have experienced acute cardiovascular events and are at risk for kidney complications.
Not a fit: Patients without a history of cardiovascular disease or those who do not have risk factors for kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent chronic kidney disease in patients recovering from heart conditions.
How similar studies have performed: Previous animal studies have shown promising results in understanding the mechanisms linking heart and kidney health, suggesting that this approach may yield valuable insights.
Where this research is happening
Portland, United States
- Portland VA Medical Center — Portland, United States (Active)
Researchers
- Principal investigator: Hutchens, Michael P — Portland VA Medical Center
- Study coordinator: Hutchens, Michael P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.