Investigating how heart rhythm affects brain health in patients with atrial fibrillation
Neurocognition and Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)
This study is looking at how fixing heart rhythm problems in people with atrial fibrillation can help protect their brain health and lower the chances of memory issues, comparing the effects of a procedure called catheter ablation to medication.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11098742 on NIH RePORTER |
What this research studies
This research focuses on patients with atrial fibrillation (AF), a common heart condition that can lead to serious cognitive issues. The study aims to understand how restoring normal heart rhythm through catheter ablation, compared to drug therapy, impacts brain health and reduces the risk of cognitive decline. By examining the relationship between heart rhythm and neurological health, the research seeks to identify methods to prevent cognitive dysfunction associated with AF. Patients will be monitored for changes in brain function and blood flow as part of this investigation.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with atrial fibrillation who are receiving oral anticoagulation therapy.
Not a fit: Patients who do not have atrial fibrillation or those who are not receiving anticoagulation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enhance brain health and reduce cognitive decline in patients with atrial fibrillation.
How similar studies have performed: Previous research has established a link between atrial fibrillation and cognitive decline, but this specific approach to restoring sinus rhythm is novel and aims to provide new insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Mathew, Joseph P — Duke University
- Study coordinator: Mathew, Joseph P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.