Investigating how heart health affects Alzheimer's risk in middle-aged adults
Midlife Vascular Risk Factors for Alzheimer's Disease in Persons with HFpEF
This study is looking at how heart health might affect the risk of developing Alzheimer's in middle-aged adults with heart failure, and it aims to find out if things like blood flow and inflammation can help us understand this connection over two years.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10980532 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between vascular risk factors and the risk of developing Alzheimer's disease in middle-aged adults who have heart failure with preserved ejection fraction (HFpEF). The study will track participants over two years, examining how factors like blood flow and inflammation may influence the accumulation of Alzheimer's biomarkers in the brain and spinal fluid. By enrolling individuals aged 45-65, the research aims to identify specific cardiovascular risks that could predict Alzheimer's disease progression in this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are middle-aged adults aged 45-65 with a diagnosis of heart failure with preserved ejection fraction (HFpEF).
Not a fit: Patients who do not have heart failure or are outside the age range of 45-65 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing Alzheimer's disease in individuals with heart health issues.
How similar studies have performed: Previous research has indicated a connection between cardiovascular health and Alzheimer's risk, suggesting that this approach may yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Butts, Brittany — Emory University
- Study coordinator: Butts, Brittany
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.