Investigating how heart health affects Alzheimer's risk in middle-aged adults

Who could benefit from this research

What this research studies

This research focuses on understanding the relationship between vascular risk factors and the risk of developing Alzheimer's disease in middle-aged adults who have heart failure with preserved ejection fraction (HFpEF). The study will track participants over two years, examining how factors like blood flow and inflammation may influence the accumulation of Alzheimer's biomarkers in the brain and spinal fluid. By enrolling individuals aged 45-65, the research aims to identify specific cardiovascular risks that could predict Alzheimer's disease progression in this vulnerable population.

Why it matters

Where this research is happening

• Emory University
  Atlanta, United States Active

Researchers

• Principal investigator: Butts, Brittany — Emory University
• Study coordinator: Butts, Brittany

Related research

Other NIH-funded projects on the same topics.

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• P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetics, behavior, and vascular data

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  NIH research Emory University · Atlanta, United States · NIH-11604417

• Sex-specific blood biomarkers predict dementia risk in older adults

  This NIH project tests how blood biomarkers and sex differences predict future dementia in older people, with the goal of personalized prognosis and prevention.

  NIH research Hennepin Healthcare Research Institute · Minneapolis, United States · NIH-11588438

• How sleep and body temperature affect Alzheimer's risk in adults with Down syndrome

  Researchers will follow adults with Down syndrome over several years to learn whether sleep problems and lower body temperature are linked to earlier Alzheimer's changes.

  NIH research New York University School of Medicine · New York, United States · NIH-11508145

• Sleep and body temperature changes linked to Alzheimer’s risk in adults with Down syndrome

  This project looks at whether sleep problems and lower body temperature in adults with Down syndrome are linked to higher chances of developing Alzheimer’s disease.

  NIH research New York University School of Medicine · New York, United States · NIH-11456945

• Sex-specific blood biomarkers to predict Alzheimer's and related dementias

  This project aims to use blood biomarkers to predict risk of Alzheimer's-related conditions in older adults, with attention to how sex differences may change risk.

  NIH research Hennepin Healthcare Research Institute · Minneapolis, United States · NIH-11416649

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.