Investigating how heart failure and aging affect diaphragm function
DO HEART FAILURE AND AGING POTENTIATE DIAPHRAGM VASCULAR DYSFUNCTION?
['FUNDING_R15'] · KANSAS STATE UNIVERSITY · NIH-10203242
This study looks at how heart failure affects the diaphragm's ability to work in older adults and tests possible treatments, like nitrate supplements, to help improve breathing and overall quality of life for those with heart failure.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | KANSAS STATE UNIVERSITY (nih funded) |
| Locations | 1 site (MANHATTAN, UNITED STATES) |
| Trial ID | NIH-10203242 on ClinicalTrials.gov |
What this research studies
This research explores the impact of heart failure on the diaphragm's ability to function in older adults. It focuses on understanding how aging and heart failure together impair oxygen transport to muscles, particularly during mechanical ventilation. The study uses animal models to investigate potential therapies, such as nitrate supplementation, that could improve diaphragm function in elderly patients suffering from heart failure. By addressing these issues, the research aims to develop targeted interventions that could enhance the quality of life for older adults with heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals suffering from heart failure or related respiratory issues.
Not a fit: Patients who are younger or do not have heart failure or significant respiratory issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diaphragm dysfunction in elderly patients with heart failure, enhancing their respiratory function and overall quality of life.
How similar studies have performed: Previous research has shown that targeting nitric oxide pathways can improve muscle oxygen delivery in similar contexts, suggesting potential for success in this approach.
Where this research is happening
MANHATTAN, UNITED STATES
- KANSAS STATE UNIVERSITY — MANHATTAN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEHNKE, BRAD J — KANSAS STATE UNIVERSITY
- Study coordinator: BEHNKE, BRAD J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.