Investigating how heart failure affects memory and cognition through microglia
The role of microglia Nek6 in myocardial infarction-induced cognitive impairment
This study is looking at how heart failure might affect memory and thinking by examining special brain cells called microglia, and it aims to help people who have heart failure and are also facing memory problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10713921 on NIH RePORTER |
What this research studies
This research explores the connection between heart failure and cognitive impairment, particularly focusing on the role of microglia, a type of immune cell in the brain. Using a mouse model that mimics human Alzheimer's risk factors, the study examines how heart failure leads to increased microglial activity and inflammation in the brain, which may contribute to memory problems. The researchers will analyze various aspects of brain inflammation and microglial behavior to understand their impact on cognitive function. This could provide insights into potential therapeutic targets for patients experiencing cognitive decline after heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of heart failure who may also be experiencing cognitive decline.
Not a fit: Patients without heart failure or those who do not exhibit cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent or mitigate cognitive impairment in patients with heart failure.
How similar studies have performed: Previous research has indicated a link between heart failure and cognitive impairment, but this specific investigation into microglial mechanisms is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Dutta, Partha — University of Pittsburgh at Pittsburgh
- Study coordinator: Dutta, Partha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.