Investigating how HDAC1 influences liver disease related to obesity and diabetes
HDAC1 as a nutrient sensor in the development and progression of NAFLD
This study is looking at how a protein called HDAC1 affects the buildup of fat in the liver and the inflammation that comes with non-alcoholic fatty liver disease (NAFLD), with the hope of finding new ways to help people manage this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11084528 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of HDAC1, a protein that regulates gene expression, in the development and progression of non-alcoholic fatty liver disease (NAFLD). The study aims to explore how changes in HDAC1 activity can affect liver fat accumulation, inflammation, and fibrosis, which are critical factors in the disease's progression. By examining these mechanisms, the research seeks to uncover potential epigenetic targets for treatment. Patients may benefit from insights that could lead to new therapeutic strategies for managing NAFLD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic fatty liver disease, particularly those who are also experiencing obesity or type 2 diabetes.
Not a fit: Patients with alcoholic liver disease or those without any liver-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse the progression of non-alcoholic fatty liver disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetic factors in metabolic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Georgia State University — Atlanta, United States (Active)
Researchers
- Principal investigator: Shi, Hang — Georgia State University
- Study coordinator: Shi, Hang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.