Investigating how HCN1 channels affect brain function and disorders.
Role of HCN1 Channels in the Function and Malfunction of Parvalbumin Positive Interneurons
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11080360
This study is looking at how certain changes in brain channels called HCN1 can cause serious childhood epilepsy and are linked to schizophrenia, with the goal of finding new ways to help treat these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11080360 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of HCN1 channels in the brain, particularly how mutations in this channel can lead to severe childhood epilepsy and are associated with schizophrenia. The study will explore the normal functioning of these channels in neurons and how their malfunction can disrupt neural activity. By examining the specific locations and behaviors of HCN1 channels in different types of neurons, researchers aim to uncover the mechanisms behind various neurological disorders. This could provide insights into potential therapeutic targets for conditions like epilepsy and schizophrenia.
Who could benefit from this research
Good fit: Ideal candidates for this research include children with severe epilepsy and individuals with schizophrenia or related symptoms.
Not a fit: Patients with neurological disorders not associated with HCN1 channel mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for childhood epilepsy and other neurological disorders linked to HCN1 channel dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding the role of ion channels in neurological disorders, indicating that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIEGELBAUM, STEVEN A — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: SIEGELBAUM, STEVEN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.