Investigating how HCMV affects immune responses in leukemia patients
HCMV-induced innate-like CD8 T cells and allogeneic HCT outcome
This study is looking at how a virus called human cytomegalovirus (HCMV) affects certain immune cells in patients with acute myeloid leukemia (AML), to see if understanding these cells can help improve treatment outcomes for those receiving transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11052659 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of human cytomegalovirus (HCMV) in the immune response of patients with acute myeloid leukemia (AML). It examines a specific type of immune cell, the NKG2C+ CD8 T cells, which may have unique properties that help fight against both HCMV and leukemia cells. By analyzing these immune cells, the research aims to uncover how HCMV influences their development and function, potentially leading to improved outcomes for patients undergoing treatments like hematopoietic cell transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia who may be undergoing or have undergone hematopoietic cell transplantation.
Not a fit: Patients with other types of leukemia or those who are not undergoing immune reconstitution therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of treatments for leukemia by leveraging the immune response to HCMV.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to HCMV, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Hsu, Katharine C — Sloan-Kettering Inst Can Research
- Study coordinator: Hsu, Katharine C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.