Investigating how H2AJ affects placental aging and structure
Official title: H2AJ as a regulator of placental senescence and genome organization
Funded at Yale University · NIH-11058454 · Data updated 2026-11-12
This study is looking at how a special protein called H2AJ affects the growth and aging of the placenta, especially in pregnancy issues like pre-eclampsia, to help find new ways to improve pregnancy health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 16, 2023 |
| Project end | April 15, 2027 |
| Funding year | 2025 |
| Award (this year) | $53,974 |
| NIH project number | 5F30HD112087-03 |
| Project ID | NIH-11058454 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals, particularly those in their first or third trimester, who may be at risk for pre-eclampsia.
✕Less likely to help
Patients who are not pregnant or those who do not have a history of placental dysfunction may not benefit from this research.
What this research studies
This research explores the role of a specific histone variant, H2AJ, in the development and aging of the placenta. By studying human embryonic stem cells, the researchers aim to understand how H2AJ influences trophoblast differentiation and the organization of the genome. The project focuses on the senescence-associated secretory phenotype (SASP) in placental dysfunction, particularly in conditions like pre-eclampsia. The findings could lead to new therapeutic strategies targeting these mechanisms to improve pregnancy outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for pre-eclampsia, potentially improving maternal and fetal health.
How similar studies have gone: Other research has shown promise in targeting senescence in placental dysfunction, suggesting that this approach could yield significant insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Jensen, Tyler Barry — Yale University
- Study coordinator: Jensen, Tyler Barry
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.