Investigating how gut proteins affect liver disease from alcohol use
The role of intestinal gp130 in alcohol-associated liver disease
This study is looking at how drinking alcohol affects your gut and liver health, and it aims to find ways to help protect your liver by focusing on certain proteins in your intestines, so if you have alcohol use disorder, your participation could help improve treatments for liver issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10742561 on NIH RePORTER |
What this research studies
This research explores the connection between alcohol use disorder and liver disease by focusing on the role of specific proteins in the gut. It examines how alcohol consumption disrupts the balance of gut bacteria and increases gut permeability, leading to liver inflammation. The study aims to restore the expression of protective proteins in the intestine to improve liver health. Patients may be involved in understanding how these gut proteins can be targeted for therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol use disorder who are experiencing liver disease.
Not a fit: Patients who do not have alcohol use disorder or liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve liver health in individuals with alcohol use disorder.
How similar studies have performed: Other research has shown promising results in targeting gut health to improve liver conditions, indicating that this approach may be effective.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Llorente Izquierdo, Ana Cristina — University of California, San Diego
- Study coordinator: Llorente Izquierdo, Ana Cristina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.