Investigating how gut microbiome metabolites affect cognitive impairment and Alzheimer's disease.
Official title: Gut microbiome-related metabolites and cognitive impairment
Funded at Massachusetts General Hospital · NIH-10984801 · Data updated 2026-11-12
This study is looking at how certain substances made by the bacteria in our gut might affect memory and thinking skills, especially for people with Alzheimer's disease, and it aims to help us understand how diet and gut health relate to brain health in different racial groups.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $825,135 |
| NIH project number | 1R01AG089361-01 |
| Project ID | NIH-10984801 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults aged 21 and older who are experiencing cognitive impairment or are at risk for Alzheimer's disease.
✕Less likely to help
Patients who do not have cognitive impairment or are not at risk for Alzheimer's disease may not benefit from this research.
What this research studies
This research explores the connection between gut microbiome-related metabolites and cognitive impairment, particularly in the context of Alzheimer's disease and vascular contributions to cognitive impairment. By analyzing data from a large, diverse cohort, the study aims to identify how these metabolites may influence disease risk and severity, especially among different racial groups. Participants will be involved in assessments that link dietary habits, gut health, and brain imaging to better understand cognitive decline. The findings could lead to new insights into prevention and treatment strategies for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for cognitive impairment and Alzheimer's disease.
How similar studies have gone: Previous studies have shown promising results in understanding the role of gut microbiome metabolites in stroke risk, suggesting potential for success in this area as well.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Kimberly, William Taylor — Massachusetts General Hospital
- Study coordinator: Kimberly, William Taylor
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.