Investigating how gut microbial enzymes affect human health and disease
Official title: Gut Microbial Enzymes and Human Disease
Funded at Univ of North Carolina Chapel Hill · NIH-11019761 · Data updated 2026-11-12
This study is looking at how certain enzymes from gut bacteria affect our health, especially in conditions like Clostridioides difficile infections, and it aims to find new ways to help manage gut-related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $482,601 |
| NIH project number | 5R35GM152079-02 |
| Project ID | NIH-11019761 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from recurrent Clostridioides difficile infections or related gut health issues.
✕Less likely to help
Patients with conditions unrelated to gut microbiota or those not experiencing gastrointestinal issues may not benefit from this research.
What this research studies
This research explores the role of gut microbial enzymes in human health and disease. By examining the structures and functions of these enzymes, the project aims to understand how they influence conditions such as Clostridioides difficile infections and other diseases related to gut health. The researchers will use targeted small molecules to modulate enzyme activities and employ advanced multi-omics approaches to gain insights into gut microbial processes. This work could lead to new therapeutic strategies for managing gut-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to gut microbiota, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in understanding gut microbiota's role in health, suggesting that this approach could yield significant insights.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Redinbo, Matthew R — Univ of North Carolina Chapel Hill
- Study coordinator: Redinbo, Matthew R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.