Investigating how gut microbes affect the development of type 2 diabetes in humans
The role of gut microbes and microbial derived metabolites in the development of type 2 diabetes in humans
This study is looking at how the tiny germs in our gut might affect the development of type 2 diabetes, and it's for people who want to understand how their gut health could be linked to this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10897298 on NIH RePORTER |
What this research studies
This research explores the connection between gut microbes and the onset of type 2 diabetes mellitus (T2DM) in humans. By analyzing fecal and plasma samples from a large Finnish cohort over 15 years, the study aims to identify specific microbial species and their metabolites that may influence the development of T2DM. The research team combines expertise in microbiome studies, metabolomics, and diabetes pathobiology to uncover potential causal relationships rather than mere associations. Patients may be monitored for changes in their gut microbiome and metabolic profiles to better understand the role these factors play in diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with type 2 diabetes, particularly those with a diverse gut microbiome.
Not a fit: Patients who do not have type 2 diabetes or are not at risk for developing it may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or managing type 2 diabetes by targeting gut microbiome health.
How similar studies have performed: Previous studies have shown promising results linking gut microbiome alterations to diabetes, but this research aims to provide more definitive causal insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Majithia, Amit — University of California, San Diego
- Study coordinator: Majithia, Amit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.