Investigating how gut infections trigger flare-ups in inflammatory bowel disease.
The Role of Enteric Infection in Flares of Inflammatory Bowel Disease
This study is looking at how certain gut infections might trigger flare-ups in people with inflammatory bowel diseases like Crohn's and ulcerative colitis, to help find better ways to manage and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10990987 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of enteric infections in causing flare-ups of inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis. Researchers will analyze the gut microbiome and its changes during these flare-ups, particularly looking at infections caused by specific pathogens like Clostridioides difficile and norovirus. By identifying how these infections contribute to inflammation, the study aims to uncover new insights that could lead to better management and treatment strategies for patients with IBD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease who experience recurrent flare-ups.
Not a fit: Patients with inflammatory bowel disease who have stable disease without recent flare-ups may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and preventive strategies for patients experiencing flare-ups of inflammatory bowel disease.
How similar studies have performed: Previous research has indicated a link between gut infections and flare-ups in IBD, suggesting that this approach has potential for significant findings.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Axelrad, Jordan Eric — New York University School of Medicine
- Study coordinator: Axelrad, Jordan Eric
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.