Investigating how gut health affects bladder cancer in older adults
Role of Gut-Immune Interactions in Aging-Associated Bladder Cancer
['FUNDING_OTHER'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-10928078
This study is looking at how the gut and immune system work together and how that might affect bladder cancer in older adults, using mice to see how age changes things and what that means for better treatments for older patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-10928078 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between gut-immune interactions and bladder cancer, particularly in older adults. It examines how aging influences the gut microbiome and inflammation, which may contribute to the development and progression of bladder cancer. By using a mouse model, researchers will compare the effects of a carcinogen on young and older mice to understand the underlying mechanisms that lead to more aggressive tumors in the elderly. The findings aim to provide insights that could improve treatment strategies for bladder cancer in older patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for or have been diagnosed with bladder cancer.
Not a fit: Patients who are younger or do not have bladder cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options and outcomes for elderly patients with bladder cancer.
How similar studies have performed: While there is existing research on gut microbiome and cancer, this specific investigation into bladder cancer in older adults is relatively novel.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOOLBRIGHT, BENJAMIN LELAND — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: WOOLBRIGHT, BENJAMIN LELAND
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.