Investigating how gut health affects Alzheimer's disease development
Gut barrier function in Alzheimer’s disease
This study is looking at how the variety of bacteria in our gut might affect the progression of Alzheimer's disease in older adults, hoping to find ways that improving gut health could help with brain health and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11018507 on NIH RePORTER |
What this research studies
This research explores the relationship between gut microbiome diversity and the progression of Alzheimer's disease (AD), particularly in older adults. It aims to understand how changes in gut bacteria may influence brain health and contribute to neurodegenerative processes. By analyzing gut microbiota and its association with biomarkers of AD, the study seeks to uncover mechanisms that could link gut health to cognitive decline. The research will involve both observational studies and potential interventions to assess the impact of gut microbiome alterations on AD pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those showing early signs of cognitive decline or diagnosed with Alzheimer's disease.
Not a fit: Patients with non-age-related cognitive impairments or those without any signs of cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing the progression of Alzheimer's disease through gut health interventions.
How similar studies have performed: Previous studies have shown promising results linking gut microbiome health to neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Bendlin, Barbara Brigitta — University of Wisconsin-Madison
- Study coordinator: Bendlin, Barbara Brigitta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.