Investigating how gut cells sense physical forces and release hormones
Role of cytoskeletal interactions with mechanogated ion channel Piezo2 in the mechanism of mechanotransduction by enteroendocrine cells
['FUNDING_FELLOWSHIP'] · MAYO CLINIC ROCHESTER · NIH-10804631
This study is looking at how special cells in your gut sense physical pressure and turn that into hormone signals, which could help us understand and improve treatments for digestive issues like irritable bowel syndrome (IBS).
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10804631 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how enteroendocrine cells (EECs) in the gastrointestinal tract detect physical forces and convert them into hormonal signals. By studying the role of the Piezo2 ion channel and its interactions with other proteins, the research aims to uncover the mechanisms behind mechanotransduction in these cells. This could lead to better insights into gastrointestinal motility disorders, such as irritable bowel syndrome (IBS), which affect a significant portion of the population. The approach involves examining the structural and functional properties of EECs and their mechanosensitive responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from functional gastrointestinal disorders, particularly those with symptoms related to motility issues.
Not a fit: Patients with non-functional gastrointestinal disorders or those without any motility-related symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for gastrointestinal motility disorders by targeting the mechanisms of hormone release in response to physical stimuli.
How similar studies have performed: Previous research has shown promising results in understanding mechanotransduction in other sensory systems, suggesting potential for success in this novel approach.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MERCADO-PEREZ, ARNALDO — MAYO CLINIC ROCHESTER
- Study coordinator: MERCADO-PEREZ, ARNALDO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.