Investigating how gut bacteria and their metabolites affect Alzheimer's disease.
Project 1 - Changes in Gut Microbiome and related Metabolome Across Trajectory of Alzheimer's Disease
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-10693925
This study is looking at how the bacteria in our gut might affect brain health, especially in people with Alzheimer's disease, and it needs participants to share samples and information to help uncover these important connections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10693925 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between the gut microbiome and Alzheimer's disease (AD) by examining how gut bacteria and their metabolites influence brain function. It utilizes advanced techniques in metagenomics and metabolomics to analyze the biochemical communication between the gut and the brain. By understanding these interactions, the research aims to identify potential metabolic changes that could contribute to the development or progression of Alzheimer's disease. Patients may be involved in providing samples and data to help uncover these connections.
Who could benefit from this research
Good fit: Ideal candidates for participation are older adults diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with non-neurodegenerative conditions or those not affected by Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease and potential therapeutic strategies targeting gut health.
How similar studies have performed: Previous research has shown promising results regarding the role of the gut microbiome in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KADDURAH-DAOUK, RIMA F — DUKE UNIVERSITY
- Study coordinator: KADDURAH-DAOUK, RIMA F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia