Investigating how gut bacteria and signaling pathways affect esophageal cancer
Official title: The Role of the Microbiome and Notch Signaling in Esophageal Adenocarcinoma
Funded at Columbia University Health Sciences · NIH-11007166 · Data updated 2026-11-12
This study is looking at how changes in gut bacteria, especially after losing a common stomach bug called Helicobacter pylori, might be linked to the increasing cases of esophageal adenocarcinoma (a type of throat cancer), and it aims to find out how these bacteria interact with the esophagus to potentially promote cancer growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $419,550 |
| NIH project number | 5R01CA255298-05 |
| Project ID | NIH-11007166 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of gastro-esophageal reflux disease or Barrett's esophagus.
✕Less likely to help
Patients without any gastrointestinal issues or those who have not been diagnosed with Barrett's esophagus or esophageal adenocarcinoma may not benefit from this research.
What this research studies
This research explores the relationship between the microbiome and Notch signaling in the development of esophageal adenocarcinoma (EAC). It aims to understand how changes in gut bacteria, particularly after the loss of Helicobacter pylori, may contribute to the rising incidence of EAC. The study will examine the mechanisms by which these bacteria interact with the esophageal lining and how this interaction may promote cancer development. By focusing on the role of bile acids and their effect on mucus production, the research seeks to uncover new insights into cancer progression.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies or treatments for esophageal adenocarcinoma.
How similar studies have gone: Previous research has shown correlations between the microbiome and esophageal conditions, but this specific approach is relatively novel.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Abrams, Julian — Columbia University Health Sciences
- Study coordinator: Abrams, Julian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.