Investigating how gut bacteria and blood chemicals affect pain after kidney transplants
The Gut Microbiome and Serum Metabolites as a Biological Mechanism Underlying Pain in Kidney Transplantation (Biome-KT)
This study is looking at how the bacteria in your gut and certain substances in your blood might be linked to the chronic pain some kidney transplant recipients feel, and it will explore how your diet and stress after the transplant could affect these factors over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11054681 on NIH RePORTER |
What this research studies
This research explores the connection between gut microbiota, serum metabolites, and chronic pain experienced by kidney transplant recipients. It aims to understand how changes in diet and stress levels after transplantation influence these biological factors and contribute to pain. By using a prospective repeated measures design, the study will track these relationships over time to identify potential mechanisms underlying pain in this population. Patients may be asked to provide samples and participate in assessments to help uncover these dynamics.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have undergone kidney transplantation and experience chronic pain.
Not a fit: Patients who have not undergone kidney transplantation or do not experience chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies for kidney transplant recipients, enhancing their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding the role of the microbiome in pain management, suggesting that this approach may yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Lockwood, Mark — University of Illinois at Chicago
- Study coordinator: Lockwood, Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.