Investigating how gut bacteria affect responses to rotavirus vaccines in infants
Gut microbial and metabolic mediators of rotavirus vaccine response
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10825430
This study is looking at how the bacteria in babies' tummies might affect how well rotavirus vaccines work, especially in places where the vaccines aren't as effective, and it will involve 330 infants from the US, Panama, and Peru to help find ways to make the vaccines better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10825430 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between gut microbiota and the immune response to rotavirus vaccines in infants. It aims to understand why the vaccine is less effective in certain regions, particularly in middle- and low-income countries. By studying the gut bacteria, specifically Bifidobacterium longum, and their role in folate synthesis, the research seeks to uncover mechanisms that could enhance vaccine efficacy. The study will involve 330 infants from the US, Panama, and Peru, analyzing both existing and newly collected samples.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants under 12 months old who are receiving the rotavirus vaccine.
Not a fit: Patients who are older than 11 years or those who have already received the rotavirus vaccine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved rotavirus vaccine effectiveness, particularly in regions where it is currently less effective.
How similar studies have performed: Previous research has indicated that gut microbiota can influence vaccine responses, suggesting that this approach has potential for success.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PANNARAJ, PIA S — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: PANNARAJ, PIA S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.