Investigating how gut bacteria affect norovirus infections in transplant patients
Official title: The role of gut microbiota in human norovirus infections in transplant patients
Funded at Ut Southwestern Medical Center · NIH-11115640 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut might affect norovirus infections, especially for transplant patients who are more at risk, to help find better ways to manage these infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | June 22, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $185,549 |
| NIH project number | 5K23AI166023-04 |
| Project ID | NIH-11115640 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adult transplant patients who have experienced symptoms of norovirus infection.
✕Less likely to help
Patients who are not transplant recipients or those without symptoms of norovirus infection may not benefit from this research.
What this research studies
This research focuses on understanding the role of gut microbiota in human norovirus infections, particularly in transplant patients who are at higher risk due to their immunosuppressed state. The study aims to identify specific gut bacteria that may influence the severity of norovirus infections and how these bacteria interact with the immune system. By collecting and analyzing stool samples from transplant patients, researchers will profile the gut microbiome to uncover patterns associated with infection outcomes. This could lead to better management strategies for norovirus infections in vulnerable populations.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment and prevention strategies for norovirus infections in transplant patients.
How similar studies have gone: Previous research has shown that gut microbiota can influence viral infections, suggesting potential for success in this novel approach.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Chong, Pearlie Pao Ee — Ut Southwestern Medical Center
- Study coordinator: Chong, Pearlie Pao Ee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.