Investigating how gut bacteria affect liver disease progression in diverse populations
Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites
['FUNDING_R01'] · UNIVERSITY OF HAWAII AT MANOA · NIH-10876975
This study is looking at how the bacteria in our gut and what we eat might affect the worsening of non-alcoholic fatty liver disease (NAFLD) over time in Asian Americans, Native Hawaiians, and Whites, and it involves tracking participants for almost ten years to learn more about these connections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF HAWAII AT MANOA (nih funded) |
| Locations | 1 site (HONOLULU, UNITED STATES) |
| Trial ID | NIH-10876975 on ClinicalTrials.gov |
What this research studies
This research examines the relationship between the gut microbiome and the progression of non-alcoholic fatty liver disease (NAFLD) over time in Asian Americans, Native Hawaiians, and Whites. By following participants for nearly a decade, the study aims to identify specific gut bacteria and dietary factors that may influence liver health. Participants will undergo assessments that include gut microbiome analysis and evaluations of liver fat and fibrosis. The goal is to better understand how these factors interact and contribute to NAFLD progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 60-77 years who are part of the Asian American, Native Hawaiian, or White populations and have or are at risk for NAFLD.
Not a fit: Patients who are younger than 60 years or do not belong to the specified racial/ethnic groups may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating liver disease based on gut health.
How similar studies have performed: Previous studies have shown associations between gut microbiome composition and liver disease, but this research aims to provide novel longitudinal insights.
Where this research is happening
HONOLULU, UNITED STATES
- UNIVERSITY OF HAWAII AT MANOA — HONOLULU, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIM, UNHEE — UNIVERSITY OF HAWAII AT MANOA
- Study coordinator: LIM, UNHEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.