Investigating how gut bacteria affect knee osteoarthritis through epigenetic changes
Cartilage Microbial Products as Novel Drivers of Knee Osteoarthritis Epigenetic Dysregulation
['FUNDING_OTHER'] · OKLAHOMA CITY VA MEDICAL CENTER · NIH-10975940
This study is looking at how changes in the bacteria in our gut, which can happen as we get older or gain weight, might affect knee osteoarthritis, and it’s for people with knee OA who are having surgery to replace their knee.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OKLAHOMA CITY VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-10975940 on ClinicalTrials.gov |
What this research studies
This research aims to explore the relationship between changes in the gut microbiome due to age and obesity and their impact on knee osteoarthritis (OA). By analyzing samples from patients with OA and healthy individuals, the study will examine how these microbiome changes are reflected in the knee cartilage and other joint areas. The researchers will focus on understanding the epigenetic alterations that may arise from microbial influences, potentially leading to new insights into OA development and treatment. Patients undergoing total knee replacement will provide paired samples for this investigation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing knee osteoarthritis.
Not a fit: Patients who are younger than 65 or do not have knee osteoarthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating knee osteoarthritis by targeting the gut microbiome.
How similar studies have performed: Previous studies have shown promising results in understanding the gut microbiome's role in osteoarthritis, suggesting that this approach could yield valuable insights.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- OKLAHOMA CITY VA MEDICAL CENTER — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JEFFRIES, MATLOCK — OKLAHOMA CITY VA MEDICAL CENTER
- Study coordinator: JEFFRIES, MATLOCK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.